Final Current: 08/02/2017 Both equally DNA sequence and also the Firm of DNA related proteins are transmitted throughout mobile divisions. This Firm is disrupted through the cell cycle, and the first composition of chromatin must be restored soon after Every cell division, a method termed ‘epigenetic memory’. This project, in collabora

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Mechanisms of signal-induced tumor chromosomal translocations situations and new chemical screens for inhibitors for breast and prostate cancer.We merge cell cycle synchronization procedures, automated ChIP-seq and computational framework to design temporal dynamics of CRs and histone modifications during the cell cycle and predict vital regulators